Discovery and optimization of 2-pyridones as dual h-DHFR/EGFRTK inhibitors with immunomodulatory potential; design, synthesis, anti-proliferative activity, and apoptosis inducer
Ahmed Ragab, Reham R. Raslan, Moustafa S. Abusaif, Hamdy Khamees Thabet, Yousry A. Ammar, Nirvana A. Gohar
Topics & Concepts
ChemistryApoptosisInducerChemical synthesisStereochemistryIn vitroPharmacologyBiochemistryGeneMedicineHER2/EGFR in Cancer ResearchSynthesis and Reactions of Organic CompoundsSynthesis and Biological Evaluation