Long-Term Expanding Porcine Airway Organoids Provide Insights into the Pathogenesis and Innate Immunity of Porcine Respiratory Coronavirus Infection
Chengfan Jiang, Liang Li, Mei Xue, Liyuan Zhao, Xiang Liu, Wenzhe Wang, Li Feng, Pinghuang Liu
Abstract
Porcine respiratory CoV (PRCoV), a natural mutant of TGEV, shows striking pathogenetic similarities to human respiratory CoV infection and provides an interesting animal model for human respiratory CoVs, including SARS-CoV-2. The lack of an in vitro model recapitulating the complicated cellularity and structure of the porcine respiratory tract is a major roadblock for the study of PRCoV infection.
Topics & Concepts
BiologyRespiratory systemInnate immune systemRespiratory tractImmunityVirologyImmunologyCoronavirusPathogenesisCoronavirus disease 2019 (COVID-19)Immune systemPathologyInfectious disease (medical specialty)DiseaseMedicineAnatomySARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections StudiesVirus-based gene therapy research