GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway
Nicholas Hoppe, Simone Harrison, Sun‐Hee Hwang, Zi-Wei Chen, Masha Karelina, Ishan Deshpande, Carl‐Mikael Suomivuori, Vivek Reddy Palicharla, Samuel P. Berry, Philipp Tschaikner, Dominik Regele, Douglas F. Covey, Eduard Stefan, Debora S. Marks, Jeremy F. Reiter, Ron O. Dror, Alex S. Evers, Saikat Mukhopadhyay, Aashish Manglik
Topics & Concepts
G protein-coupled receptorCell biologySmoothenedHedgehogHedgehog signaling pathwaySignal transductionBiologyCiliumHeterotrimeric G proteincAMP-dependent pathwayGLI2G proteinChemistryHedgehog Signaling Pathway StudiesGenetics and Neurodevelopmental DisordersCongenital Ear and Nasal Anomalies