<scp>Metal‐Free</scp> Synthesis of Benzo[<i>a</i>]phenanthridines from Aromatic Aldehydes, Cyclohexanones, and Aromatic Amines
Pingyu Jiang, Zhifei Shan, Shanping Chen, Quanyuan Wang, Shuxin Jiang, Haolin Zheng, Guo‐Jun Deng
Abstract
Comprehensive Summary A three‐component synthesis of benzo[ α ]phenanthridines from aromatic aldehydes, cyclohexanones, and aromatic amines has been developed, which is mediated by KI/DMSO/camphorsulfonic acid to afford a variety of functionalized benzo[ α ]phenanthridines in satisfactory yields. The present strategy provides a biaryl motif ortho to the nitrogen atom which has the potential to be used as ligand by further modification. With the advantages of readily available starting materials, transition‐metal‐free conditions, gram‐scale synthesis, and broad substrate scope, this three‐component protocol provides an efficient approach for the preparation of diverse benzo[ α ]phenanthridines.