Mitochondrial Metabolism in Hibernation: Regulation and Implications
James F. Staples, Katherine E. Mathers, Brynne M. Duffy
Abstract
Hibernators rapidly and reversibly suppress mitochondrial respiration and whole animal metabolism. Posttranslational modifications likely regulate these mitochondrial changes, which may help conserve energy in winter. These modifications are affected by reactive oxygen species (ROS), so suppressing mitochondrial ROS production may also be important for hibernators, just as it is important for surviving ischemia-reperfusion injury.
Topics & Concepts
Hibernation (computing)MitochondrionReactive oxygen speciesEnergy metabolismCellular respirationCell biologyRespirationMetabolismBiologyMitochondrial ROSOxygen metabolismBiochemistryOxygenChemistryAnatomyEndocrinologyComputer scienceState (computer science)Organic chemistryAlgorithmAdipose Tissue and MetabolismBat Biology and Ecology StudiesExercise and Physiological Responses