Yeast synaptobrevin, Snc1, engages distinct routes of postendocytic recycling mediated by a sorting nexin, Rcy1-COPI, and retromer
Jordan T. Best, Peng Xu, Jack G. McGuire, Shannon Leahy, Todd R. Graham
Abstract
The yeast synaptobrevin, Snc1, uses multiple modes of postendocytic recycling to facilitate its return to either the trans-Golgi network or the plasma membrane. Snc1 primarily recycles via pathways dependent on either Rcy1/COPI or Snx4, while a smaller portion of the SNARE appears to be capable of being retrieved by retromer.
Topics & Concepts
RetromerBiologySorting nexinCOPICell biologyGolgi apparatusYeastVesicular Transport ProteinsSaccharomyces cerevisiaeEndosomeGeneticsVacuolar protein sortingSecretory pathwayEndoplasmic reticulumIntracellularCellular transport and secretionEndoplasmic Reticulum Stress and DiseaseLipid Membrane Structure and Behavior