Size-advantage of monovalent nanobodies against the macrophage mannose receptor for deep tumor penetration and tumor-associated macrophage targeting
Marco Erreni, Francesca D’Autilia, Roberta Avigni, Evangelia Bolli, Sana M. Arnouk, Kiavash Movahedi, Pieterjan Debie, Achille Anselmo, Raffaella Parente, Cécile Vincke, Fijs W. B. van Leeuwen, Paola Allavena, Cecília Garlanda, Alberto Mantovani, Andrea Doni, Sophie Hernot, Jo A. Van Ginderachter
Abstract
These data describe, for the first time, a microscopic analysis of (m) and (biv)anti-MMR Nb pharmacokinetics in tumor and healthy tissues. The concepts proposed in this study provide important knowledge for the future use of Nbs as diagnostic and therapeutic agents, especially for the targeting of tumor-infiltrating immune cells.
Topics & Concepts
Mannose receptorIn vivoMacrophageTumor-associated macrophageCancer researchPathologyConfocal microscopyImmunohistochemistryChemistryMedicineBiologyIn vitroCell biologyBiochemistryBiotechnologyMonoclonal and Polyclonal Antibodies ResearchImmunotherapy and Immune ResponsesGlycosylation and Glycoproteins Research