Seneca Valley Virus Enters PK-15 Cells via Caveolae-Mediated Endocytosis and Macropinocytosis Dependent on Low-pH, Dynamin, Rab5, and Rab7
Lei Hou, Xinxin Tong, Yang Pan, Ruihan Shi, Changzhe Liu, Jinshuo Guo, Yongyan Shi, Xiaoyu Yang, Yong Wang, Xufei Feng, Jianwei Zhou, Jue Liu
Abstract
Entry of virus into cells represents the initiation of a successful infection. As an emerging pathogen of porcine vesicular disease, clarification of the process of SVV entry into cells enables us to better understand the viral life cycle and pathogenesis.
Topics & Concepts
EndocytosisDynaminPinocytosisCaveolaeBiologyClathrinInternalizationCell biologyViral entryCaveolinSmall interfering RNAWortmanninViral replicationKinaseSignal transductionCell cultureVirusVirologyPhosphatidylinositolTransfectionCellBiochemistryGeneticsRNA regulation and diseaseCellular transport and secretionRNA Research and Splicing