Co(III)-Catalyzed C6-Selective C–H Activation/Pyridine Migration of 2-Pyridones with Propiolates
Yuelu Zhu, Na Zhao, Xin-Long Fu, Xinyang Zhao, Yan-Lin Li, You‐Dong Shao, Jiao Chen, Yi Lu
Abstract
A versatile Co(III)-catalyzed C6-selective C-H activation/pyridine migration of 2-pyridones with available propiolates as coupling partners was demonstrated. This method features high atom economy, excellent regioselectivity, and good functional group tolerance by employing an inexpensive Co(III) catalyst under mild reaction conditions. Moreover, gram-scale synthesis and late-stage modifications of pharmaceuticals were performed to prove the effectiveness of these synthetic approaches.
Topics & Concepts
ChemistryCatalysisPyridineRegioselectivityCombinatorial chemistryFunctional groupAtom economyReaction conditionsMedicinal chemistryOrganic chemistryPolymerCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsCyclopropane Reaction Mechanisms