The Role of lncRNA in the Development of Tumors, including Breast Cancer
Beata Smolarz, Anna Zadrożna-Nowak, Hanna Romanowicz
Abstract
Long noncoding RNAs (lncRNAs) are the largest groups of ribonucleic acids, but, despite the increasing amount of literature data, the least understood. Given the involvement of lncRNA in basic cellular processes, especially in the regulation of transcription, the role of these noncoding molecules seems to be of great importance for the proper functioning of the organism. Studies have shown a relationship between disturbed lncRNA expression and the pathogenesis of many diseases, including cancer. The present article presents a detailed review of the latest reports and data regarding the importance of lncRNA in the development of cancers, including breast carcinoma.
Topics & Concepts
BiologyBreast cancerLong non-coding RNATranscription (linguistics)Computational biologyCancerBioinformaticsPathogenesisTranscription factorOrganismCancer researchRNAGeneGeneticsImmunologyLinguisticsPhilosophyCancer-related molecular mechanisms researchRNA modifications and cancerRNA Research and Splicing