Are patients with chronic rhinosinusitis with nasal polyps at a decreased risk of COVID‐19 infection?
Fatemeh Saheb Sharif‐Askari, Narjes Saheb Sharif‐Askari, Swati Goel, Samer Fakhri, Saleh Al Muhsen, Qutayba Hamid, Rabih Halwani
Abstract
Supplementary Table 1. General characteristics of CRSsNP and CRSwNP cohorts (GSE36830). Supplementary Table 2. General characteristics of eosinophilic CRSwNP and non-eosinophilic CRSwNP cohorts (GSE72713). Supplementary Figure 1. (A) Positive correlation between ACE2 and IFN-g (r=0.86, P=0.003) and negative correlation between ACE2 and (B) IL5 (r=0.709, P=033) and (C) IL13 (r=0.682, P=043). Supplementary Figure 2. The effect of cytokines on the gene expression levels of ACE2 and TMPRSS2 in nasal cells. (A-C) Gene expression level of ACE2 and TMPRSS2 in human ethmoid sinus cells treated or not with IFNγ, IL17, and IL4. The data shows that treatment with IFNγ or IL17 upregulated ACE2 and TMPRSS2 expression in these cells; while IL4 suppressed their expression levels. (D) Gene expression level of ACE2 and TMPRSS2 in human nasal epithelial cells treated or not with IL13. The data shows that treatment with IL13 downregulated ACE2 expression, but increased TMPRSS2 expression in these cells. Supplementary Figure 3. (A) The gene expression levels of extracellular matrix depositions such as α-SMA (ACTA2), Fibronectin (FN1), and Collagen type I (COL1A1) in the uncinate tissue of CRSsNP compared to nasal polyps of CRSwNP. The presented data shows that ECM depositions are non-significant between uncinate tissues of CRSsNP and nasal polyps of CRSwNP. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.