Cobalt-Catalyzed Alkylation of Nitriles with Alcohols
Arpita Singh, Michael Findlater
Abstract
Herein, we report an operationally convenient, cobalt-catalyzed alkylation of aryl nitriles employing primary and secondary alcohols (>30 examples, up to 86% yield). The use of readily available cobalt precursors and the widely employed BIAN (BIAN = bis(arylimino)acenaphthene) ligand affords an efficient catalytic reaction that is environmentally benign, leading to the formation of water as the only byproduct.
Topics & Concepts
ChemistryCobaltAcenaphtheneAlkylationCatalysisYield (engineering)Primary (astronomy)ArylLigand (biochemistry)Organic chemistryCombinatorial chemistryAlkylNaphthaleneAstronomyMaterials sciencePhysicsReceptorBiochemistryMetallurgyAsymmetric Hydrogenation and CatalysisCatalytic C–H Functionalization MethodsChemical Synthesis and Analysis