Cardiac PANK1 deletion exacerbates ventricular dysfunction during pressure overload
Timothy N. Audam, Caitlin M. Howard, Lauren F. Garrett, Yi Zheng, James Bradley, Kenneth R. Brittian, Matthew W. Frank, Kyle Fulghum, Miklós Pólos, Szilvia Herczeg, Béla Merkely, Tamás Radovits, Shizuka Uchida, Bradford G. Hill, Sujith Dassanayaka, Suzanne Jackowski, Steven P. Jones
Abstract
Changes in CoA homeostasis have been implicated in a variety of metabolic diseases; however, the extent to which changes in CoA homeostasis impacts remodeling has not been explored. We show that limiting cardiac CoA levels via PANK deletion exacerbated ventricular remodeling during pressure overload. Our results suggest that metabolic alterations, rather than structural alterations, associated with Pank1 deletion may underlie the exacerbated cardiac phenotype during pressure overload.