Inhibition of tumor progression and M2 microglial polarization by extracellular vesicle-mediated microRNA-124 in a 3D microfluidic glioblastoma microenvironment
Soohyun Hong, Jae Young You, Kyurim Paek, Jubin Park, Su Jin Kang, Eun Hee Han, Nakwon Choi, Seok Chung, Won Jong Rhee, Jeong Ah Kim
Abstract
In this study, we demonstrated that EV-mediated miR-124 delivery exerted synergistic anti-tumor effects by suppressing the growth of human GBM cells and inhibiting M2 microglial polarization. These findings provide new insights toward a better understanding of the GBM microenvironment and provide substantial evidence for the development of potential therapeutic strategies using miRNA-loaded EVs.
Topics & Concepts
MicrogliaU87microRNACancer researchMicrovesiclesTumor microenvironmentExtracellular vesicleSTAT proteinCytokineGliomaBiologyCell biologyChemistrySignal transductionSTAT3ImmunologyInflammationTumor cellsGeneBiochemistryExtracellular vesicles in diseaseMicroRNA in disease regulationNanoplatforms for cancer theranostics