Iron-Catalyzed Aerobic α,β-Dehydrogenation
Guo-Qing Jiang, Bin-Hong Han, Xian-Peng Cai, Jian‐Ping Qu, Yan‐Biao Kang
Abstract
An iron-catalyzed direct aerobic α,β-dehydrogenation of carbonyls has been reported. The combination of tert -butyl nitrite and N -hydroxyphthalimide worked as the organo cocatalyst system; thus, no extra transition metal reagents are required. A large variety of lactams and flavanones as well as lactone and thiochromen-4-one could be produced via this method in high yields.
Topics & Concepts
DehydrogenationChemistryCatalysisReagentCombinatorial chemistryNitriteTransition metalOrganic chemistryNitrateCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsAsymmetric Hydrogenation and Catalysis