Prevention of acetaminophen-induced hepatocyte injury: JNK inhibition and GSTA1 involvement
Yicong Chang, Jingshan He, Bingke Ma, Muhammad Ishfaq, Jiaqi Wang, Ruichen Zhang, Yuan Liang, Jiarui Liu, Changwen Li, Fangping Liu
Topics & Concepts
HepatocyteAcetaminophenOxidative stressLiver injuryKinaseApoptosisSignal transductionPhosphorylationDetoxification (alternative medicine)ChemistryPharmacologyGlutathioneCell biologyMedicineEnzymeBiochemistryBiologyIn vitroPathologyAlternative medicineDrug-Induced Hepatotoxicity and ProtectionGlutathione Transferases and PolymorphismsGenomics, phytochemicals, and oxidative stress