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GMP-grade nanoparticle targeted to nucleolin downregulates tumor molecular signature, blocking growth and invasion, at low systemic exposure

Nuno A. Fonseca, Ana C. Gregório, Vera M. Mendes, Rui M. Lopes, Teresa R. Abreu, Nélio Gonçalves, Bruno Manadas, Manuela Lacerda, Paulo Figueiredo, Marta Isabel Pereira, Maria Manuela Gaspar, Fabiana Colelli, Daniela Pesce, Giacomo Signorino, Laura Focareta, Alessandra Fucci, Francesco Cardile, Claudio Pisano, Tony F. Cruz, Luís Almeida, Vera Moura, Sérgio Simões, João Nuno Moreira

2021Nano Today27 citationsDOIOpen Access PDF

Topics & Concepts

NucleolinDoxorubicinCancer researchMedicinePharmacologyDownregulation and upregulationChemistryChemotherapyInternal medicineGeneNucleusPsychiatryBiochemistryNucleolusAdvanced biosensing and bioanalysis techniquesRNA modifications and cancerRNA Interference and Gene Delivery
GMP-grade nanoparticle targeted to nucleolin downregulates tumor molecular signature, blocking growth and invasion, at low systemic exposure | Litcius