PET Imaging of Self‐Assembled <sup>18</sup>F‐Labelled Pd<sub>2</sub>L<sub>4</sub> Metallacages for Anticancer Drug Delivery
Raúl Cosialls, Cristina Simó, Salvador Borrós, Vanessa Gómez‐Vallejo, Claudia Schmidt, Jordi Llop, Ana B. Cuenca, Angela Casini
Abstract
Abstract To advance the design of self‐assembled metallosupramolecular architectures as new generation theranostic agents, the synthesis of 18 F‐labelled [Pd 2 L 4 ] 4+ metallacages is reported. Different spectroscopic and bio‐analytical methods support the formation of the host‐guest cage‐cisplatin complex. The biodistribution profiles of one of the cages, alone or encapsulating cisplatin have been studied by PET/CT imaging in healthy mice in vivo, in combination to ICP‐MS ex vivo.
Topics & Concepts
BiodistributionCisplatinIn vivoEx vivoDrug deliveryPet imagingChemistryRadiochemistryNanotechnologyNuclear medicineMaterials sciencePositron emission tomographyIn vitroMedicineChemotherapyBiochemistryBiotechnologySurgeryBiologySupramolecular Chemistry and ComplexesMolecular Sensors and Ion DetectionSupramolecular Self-Assembly in Materials