A simple but novel glycymicelle ophthalmic solution based on two approved drugs empagliflozin and glycyrrhizin: <i>in vitro</i>/<i>in vivo</i> experimental evaluation for the treatment of corneal alkali burns
Zongjian Sun, Mingxin Zhang, Yanjun Wei, Mengshuang Li, Xianggen Wu, Meng Xin
Abstract
A simple but novel ophthalmic solution based on two approved drugs (empagliflozin and glycyrrhizin) was developed with a significant effect against corneal alkali burns in mice involving the mechanism of inhibiting HMGB1 signaling.
Topics & Concepts
EmpagliflozinGlycyrrhizinIn vivoPharmacologyChemistryIn vitroMedicineBiochemistryBiologyEndocrinologyBiotechnologyDiabetes mellitusType 2 Diabetes MellitusAdvanced Glycation End Products researchOcular Surface and Contact LensAdenosine and Purinergic Signaling