Optimization of a peptide ligand for the adhesion GPCR ADGRG2 provides a potent tool to explore receptor biology
Yujing Sun, Daolai Zhang, Ming‐liang Ma, Hui Lin, Youchen Song, Junyan Wang, Chuanshun Ma, Ke Yu, Wentao An, Shengchao Guo, Dongfang He, Zhao Yang, Peng Xiao, Gui‐Ge Hou, Xiao Yu, Jin‐Peng Sun
Abstract
and residues of the ECL2 region of ADGRG2 are key determinants for VPM-p15 interactions and VPM-p15-induced Gs or arrestin signaling. Our study not only provides a useful tool to investigate the function of ADGRG2 but also offers new insights to guide further optimization of Stachel peptides to activate adhesion GPCR members.
Topics & Concepts
G protein-coupled receptorComputational biologyReceptorLigand (biochemistry)PeptideBiologyCell biologyBiochemistryReceptor Mechanisms and SignalingNeuropeptides and Animal PhysiologyMonoclonal and Polyclonal Antibodies Research