Mucosal Immune Profiles Associated with Diarrheal Disease Severity in<i>Shigella</i>- and Enteropathogenic Escherichia coli-Infected Children Enrolled in the Global Enteric Multicenter Study
Amanda D. Buskirk, Esther Ndungo, Avital A. Shimanovich, Diana Lam, William C. Blackwelder, Usman N. Ikumapayi, Bing Ma, Helen Powell, Martín Antonio, James P. Nataro, James B. Kaper, Marcela F. Pasetti
Abstract
with and without dysentery, and controls in well characterized clinical samples obtained during the Global Enteric Multicenter Study. For the first time, we report pathogen-specific mucosal immune profiles associated with severity or absence of disease in children <5 years of age that can inform prevention and treatment efforts.
Topics & Concepts
ShigellaDiarrheaEnteropathogenic Escherichia coliImmunologyImmune systemDysenteryMedicineMicrobiologyShigella dysenteriaeBiologySalmonellaInternal medicineEscherichia coliBacteriaBiochemistryGeneticsGeneEscherichia coli research studiesViral gastroenteritis research and epidemiologyWhipple's Disease and Interleukins