<i>Atractylodes macrocephala</i> Rhizomes Contain Anti-inflammatory Sesquiterpenes
Cao Thanh Hải, Nguyễn Thị Luyến, Đỗ Hoàng Giang, Bùi Quang Minh, Nguyễn Quang Trung, Phạm Thế Chính, Dang Viet Hau, Nguyễn Tiến Đạt
Abstract
Two new compounds, named eudesm-4(15),7-diene-3α,9β,11-triol (1) and eudesm-4(15),7-diene-1β,3α,9β,11-tetraol (2) together with three known sesquiterpene lactones (1S,5R,7R,10R)-secoatractylolactone (3), (1S,5R,7R,10R)-secoatractylolactone-11-O-β-D-glucopyranoside (4) atractylenolide III (5) were isolated from the rhizomes of Atractylodes macrocephala. Their structures were elucidated by using 1D and 2D-NMR spectra and HRESIMS data. Compound 5 exhibited the most active anti-inflammatory activity with IC50 values of 27.5 μM in inhibiting of nitric oxide production. Compounds 1, 2, and 3 showed moderate effects while compound 4 was inactive.