Photosensitizer-loaded hydrogels for photodynamic inactivation of multirestistant bacteria in wounds
Sarah Glaß, Mathias Kühnert, Norman Lippmann, Joanne Zimmer, Robert Werdehausen, Bernd Abel, Volker Eulenburg, Agnes Schulze
Abstract
, was successfully demonstrated. In general, TMPyP-loaded hydrogels were more effective than THPTS-loaded ones. Nevertheless, both photosensitizers displayed effectivity against all investigated bacteria strains. Taken together, our data demonstrate that photosensitizer-loaded hydrogels are a promising new tool to improve the treatment of wounds infected with problematic bacterial pathogens.
Topics & Concepts
PhotosensitizerSelf-healing hydrogelsPhotodynamic therapyBacteriaChemistryBiophysicsPhotochemistryPolymer chemistryBiologyOrganic chemistryGeneticsPhotodynamic Therapy Research StudiesOcular Infections and TreatmentsNanoplatforms for cancer theranostics