Mechanistic Insights to Combating NDM- and CTX-M-Coproducing Klebsiella pneumoniae by Targeting Cell Wall Synthesis and Outer Membrane Integrity
Nicholas M. Smith, Katie Rose Boissonneault, Liang Chen, Vidmantas Petraitis, Rūta Petraitienė, Xun Tao, Jieqiang Zhou, Yinzhi Lang, Povilas Kavaliauskas, Zackery P. Bulman, Patricia N. Holden, Raymond Cha, Jürgen B. Bulitta, Barry N. Kreiswirth, Thomas J. Walsh, Brian T. Tsuji
Abstract
< 0.05), indicating a decreased inflammatory process. Altogether, adding polymyxin B to the combination of aztreonam plus ceftazidime-avibactam for NDM- and CTX-M-producing K. pneumoniae improved bacterial killing effects, reduced lung inflammation, suppressed resistance amplification, and limited virulence changes.
Topics & Concepts
Klebsiella pneumoniaeMicrobiologyBacterial outer membraneBiologyEscherichia coliGeneticsGeneAntibiotic Resistance in BacteriaBacterial biofilms and quorum sensingBacterial Genetics and Biotechnology