Cobalt-Catalyzed Diastereoselective and Enantioselective Hydrosilylation of Achiral Cyclopropenes
Longyang Dian, Ilan Marek
Abstract
A mild diastereoselective and enantioselective cobalt-catalyzed hydrosilylation reaction of achiral cyclopropenes has been developed. In this protocol, various substituted cyclopropenes and arylsilanes were transformed, in the presence of readily available chiral cobalt complex, into silylcyclopropanes with high selectivities.
Topics & Concepts
HydrosilylationEnantioselective synthesisCobaltChemistryCatalysisOptically activeCombinatorial chemistryReaction conditionsOrganic chemistryStereochemistryMedicinal chemistryCyclopropane Reaction MechanismsCatalytic C–H Functionalization MethodsCatalytic Alkyne Reactions