Comprehensive study of pydiflumetofen in Danio rerio: Enantioselective insight into the toxic mechanism and fate
Zhen Wang, Yuting Tan, Yanhong Li, Jinsheng Duan, Qiqi Wu, Rui Li, Haiyan Shi, Minghua Wang
Abstract
(7.37 at 0.05 mg/L and 14.69 at 0.2 mg/L). Besides, muscle is an important tissue for PYD accumulation, existing potential food risk. Eleven PYD metabolites were qualitatively identified, and the metabolic pathway was proposed, including hydroxylation, N-demethylation, demethoxylation, hydrolysation (phase Ⅰ), and acetylation and glucuronidation (phase Ⅱ). The predicted toxicity of the metabolite indicated that several highly toxic metabolites need to be considered in the future. This study provides a new perspective for evaluating the ecological and human health risks of chiral pesticides.
Topics & Concepts
DanioMetaboliteChemistryDevelopmental toxicityBioaccumulationToxicityHydroxylationMetabolismBiochemistryPharmacologyBiologyEnvironmental chemistryZebrafishEnzymeGeneticsGeneOrganic chemistryGestationPregnancyMetabolomics and Mass Spectrometry StudiesAnalytical Chemistry and ChromatographyPharmaceutical and Antibiotic Environmental Impacts