Lipid-Lowering Meroterpenoids Penihemeroterpenoids A–F from <i>Penicillium herquei</i> GZU-31-6 via Targeting the AMPK/ACC/SREBP-1c Signaling Pathway
Huimei Deng, Jingxin He, Binglin Chang, Qingcui Li, Yena Liu, Zhongxiang Zhao, Zhongqiu Liu, Hui Cui
Abstract
Penihemeroterpenoids A–C, the first meroterpenoids with an unprecedented 6/5/6/5/5/6/5 heptacyclic ring system, together with precursors penihemeroterpenoids D–F, were co-isolated from the fungus Penicillium herquei GZU-31-6. Among them, penihemeroterpenoids C–F exhibited lipid-lowering effects comparable to those of the positive control simvastatin by the activation of the AMPK/ACC/SREBP-1c signaling pathway, downregulated the mRNA levels of lipid synthesis genes FAS and PNPLA3, and increased the level of mRNA expression of the lipid export gene MTTP.
Topics & Concepts
ChemistrySterol regulatory element-binding proteinAMPKSimvastatinSignal transductionMessenger RNAGeneBiochemistryGene expressionPhosphorylationEndocrinologyBiologyProtein kinase APlant biochemistry and biosynthesisMicrobial Natural Products and BiosynthesisMicrobial Metabolic Engineering and Bioproduction