PM2.5 and Serum Metabolome and Insulin Resistance, Potential Mediation by the Gut Microbiome: A Population-Based Panel Study of Older Adults in China
Liang Zhao, Jianlong Fang, Song Tang, Fuchang Deng, Xiaohui Liu, Yu Shen, Yuanyuan Liu, Fanling Kong, Yanjun Du, Liangliang Cui, Wanying Shi, Yan Wang, Jiaonan Wang, Yingjian Zhang, Xiaoyan Dong, Ying Gao, Li Dong, Huichan Zhou, Qinghua Sun, Haoran Dong, Xiumiao Peng, Yi Zhang, Meng Cao, Yanwen Wang, Hong Zhi, Hang Du, Jingyang Zhou, Tiantian Li, Xiaoming Shi
Abstract
BACKGROUND: , gut microbiota, and metabolic diseases are unclear. OBJECTIVES: and sphingolipid metabolism. METHODS: ) and featured metabolism outcomes. RESULTS: exposure may contribute to systemic inflammation and altered sphingolipid metabolism. DISCUSSION: and IR. https://doi.org/10.1289/EHP9688.
Topics & Concepts
MetabolomeMediationSphingolipidMedicineMetabolomicsInsulinDiabetes mellitusPhysiologyAssociation (psychology)EndocrinologyInternal medicineBioinformaticsBiologyMetforminChinaType 2 diabetesInsulin resistanceConfoundingMEDLINEOxidative stressCase-control studyMutationTranscriptomeInsulin receptorBiomarkerObesityGut microbiota and healthMetabolomics and Mass Spectrometry StudiesChronic Obstructive Pulmonary Disease (COPD) Research