Access to cyano-substituted pyrazolines through copper-catalyzed cascade cyanation/cyclization of unactivated olefins
Fei Meng, Fang Qin, Weidong Yuan, Ning Xu, Shujun Cao, Jianlin Chun, Jie Li, Honglin Zhang, Yingguang Zhu
Abstract
A mild copper-catalyzed cascade cyanation/cyclization of hydrazone-tethered unactivated olefins was developed for the efficient and practical synthesis of cyano-containing pyrazolines.
Topics & Concepts
CyanationChemistryCascadeHydrazoneCatalysisCopperCombinatorial chemistryOrganic chemistryMedicinal chemistryChromatographyCatalytic C–H Functionalization MethodsSulfur-Based Synthesis TechniquesSynthesis and Catalytic Reactions