Synthesis, study of antileishmanial and antitrypanosomal activity of imidazo pyridine fused triazole analogues
Adinarayana Nandikolla, Singireddi Srinivasarao, Banoth Karan Kumar, Sankaranarayanan Murugesan, Himanshu Aggarwal, Louise L. Major, Terry Smith, Kondapalli Venkata Gowri Chandra Sekhar
Abstract
toxicity profile suggested that the tested compounds would be non-toxic, which was confirmed experimentally by the lack of cytotoxicity against HeLa cells. Finally, a molecular docking study was also performed, for 10d the most active antileishmanial compound, to study its putative binding pattern at the active site of the selected leishmanial trypanothione reductase target.
Topics & Concepts
ChemistryIn silicoStereochemistryLipinski's rule of fiveHeLaADMEPyridineDocking (animal)1,2,3-TriazoleCytotoxicityActive siteTrypanosoma bruceiBromideStructure–activity relationshipIn vitroBiochemistryEnzymeOrganic chemistryNursingGeneMedicineResearch on Leishmaniasis StudiesTrypanosoma species research and implicationsClick Chemistry and Applications