Direct Arylation of Azoles Enabled by Pd/Cu Dual Catalysis
Tiffany Piou, Yuriy Slutskyy, Nancy J. Kevin, Zhongxiang Sun, Dong Xiao, Jongrock Kong
Abstract
A practical approach toward the synthesis of 2-arylazoles via direct arylation is described. The transformation relies on a Pd/Cu cocatalyst system that operates with low catalyst loadings. The reaction conditions were found to be tolerant of a wide range of functional groups and nitrogen-containing heterocycles commonly employed in a drug discovery setting.
Topics & Concepts
ChemistryCatalysisCombinatorial chemistryPalladiumDual (grammatical number)Reaction conditionsFunctional groupOrganic chemistryLiteratureArtPolymerCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsCatalytic Alkyne Reactions