Novel anti-inflammatory agents featuring phenoxy acetic acid moiety as a pharmacophore for selective COX-2 inhibitors: Synthesis, biological evaluation, histopathological examination and molecular modeling investigation
Mohamed K. Elgohary, Mahmoud F. Abo-Ashour, Soha R. Abd El Hadi, Mahmoud A. El Hassab, Mohammed E. Abo‐El Fetoh, Hassan Afify, Hatem A. Abdel‐Aziz, Sahar M. Abou‐Seri
Topics & Concepts
PharmacophoreChemistryPharmacologyMoietyNonsteroidalCyclooxygenaseAnti-inflammatoryDrugAcetic acidPyrazolineCombinatorial chemistryEnzymeBiochemistryStereochemistryOrganic chemistryMedicineInflammatory mediators and NSAID effectsSynthesis and biological activitySynthesis and Reactions of Organic Compounds