Emerging roles of GPR109A in regulation of neuroinflammation in neurological diseases and pain
Han‐Rong Weng, Kyle Taing, Lawrence Chen
Abstract
Neuroinflammation plays a critical role in the pathological process of multiple neurological disorders and pathological pain conditions. GPR109A, a Gi protein-coupled receptor, has emerged as an important therapeutic target for controlling inflammation in various tissues and organs. In this review, we summarized current data about the role of GPR109A in neuroinflammation. Specifically, we focused on the pharmacological features of GPR109A and signaling pathways used by GPR109A to ameliorate neuroinflammation and symptoms in Alzheimer's disease, Parkinson's disease, multiple sclerosis, stroke, and pathological pain conditions.
Topics & Concepts
NeuroinflammationMultiple sclerosisPathologicalMedicineDiseaseNeuroscienceStroke (engine)InflammationImmunologyPsychologyInternal medicineEngineeringMechanical engineeringNeuropeptides and Animal PhysiologyReceptor Mechanisms and SignalingPharmacological Receptor Mechanisms and Effects