Tofacitinib for the Treatment of Pouch-Related Disorders: A Case Series
Rahul S. Dalal, Kanwal Bains, Jenna Marcus, Emma McClure, Jessica R. Allegretti
Abstract
Lay Summary In this case series, 6 patients with chronic pouchitis (n = 3), cuffitis (n = 2), or Crohn’s-like disease of the pouch (n = 1) were treated with tofacitinib. One patient achieved clinical response; however, all patients ultimately discontinued therapy due to nonresponse or adverse events.
Topics & Concepts
TofacitinibPouchitisMedicinePouchAdverse effectCrohn's diseaseInflammatory bowel diseaseGastroenterologyInternal medicineSeries (stratigraphy)DermatologyDiseaseSurgeryRheumatoid arthritisBiologyPaleontologyImmunodeficiency and Autoimmune DisordersAutoimmune and Inflammatory DisordersEosinophilic Esophagitis