Design and Synthesis of Novel Double-Ring Conjugated Enones as Potent Anti-rheumatoid Arthritis Agents
Shiyang Zhou, Wenming Jiang, Guang‐Ying Chen, Gangliang Huang
Abstract
could effectively inhibit the increase of TNF-α, IL-1β, and IL-6 induced by LPS and regulate the expression of TLR4, MyD88, NF-κB, and IκB in the signaling pathway of TLR4/NF-κB. Our results provided a promising starting point for the development of highly effective small molecules for the treatment of RA.
Topics & Concepts
Rheumatoid arthritisIn vivoArthritisSynovitisMedicineIn vitroMethotrexateConjugated systemPharmacologyTumor necrosis factor alphaChemistryImmunologyBiologyBiochemistryBiotechnologyPolymerOrganic chemistrySynthesis and biological activityQuinazolinone synthesis and applicationsSynthesis and Characterization of Heterocyclic Compounds