Medium-chain fatty acid oxidation is independent of <scp>l</scp>-carnitine in liver and kidney but not in heart and skeletal muscle
Andrea S. Pereyra, Kelsey McLaughlin, Katherine A. Buddo, Jessica M. Ellis
2023American Journal of Physiology-Gastrointestinal and Liver Physiology55 citationsDOIOpen Access PDF
Abstract
This work demonstrates that the traditional concept of mitochondrial medium-chain fatty acid oxidation as unregulated and independent of carnitine applies only to liver metabolism, and to kidney to a lesser extent, but not the heart or skeletal muscle. Thus, the benefits of dietary medium-chain fatty acids are set by liver metabolic activity and peripheral tissues are unlikely to receive direct benefits from medium-chain fatty acid metabolism, but rather metabolic byproducts of liver's medium-chain oxidative metabolism.
Topics & Concepts
CarnitineSkeletal muscleBeta oxidationKidneyChemistryBiochemistryFatty acidInternal medicineMedicineMetabolism and Genetic DisordersDiet and metabolism studiesMuscle metabolism and nutrition