A novel 3D printed type II silk fibroin/polycaprolactone mesh for the treatment of pelvic organ prolapse
Jingya Wu, Hai Yao, Lili Yu, Huawen Li, Yan Zuo, Wenjun Liu, Chunye Zhang, Caili Fu, Mubiao Liu
Abstract
degradation assay. Furthermore, biocompatibility tests conducted on mouse embryonic fibroblasts (NIH/3T3) revealed enhanced cell affinity. Finally, the biocompatibility and tissue repair properties of PCL/SF mesh were verified through the implantation of meshes in the muscle defect site of mice. The results demonstrated that the 3D printed PCL/SF mesh prepared by EHDP exhibits superior mechanical properties, biocompatibility, biodegradability, as well as ligament and muscle fiber repair ability. The novel implantable meshes are promising for curing POP.
Topics & Concepts
BiocompatibilityFibroinPolycaprolactoneBiomedical engineeringMaterials scienceSILKPolygon meshMedicineComputer scienceComposite materialPolymerMetallurgyComputer graphics (images)Pelvic floor disorders treatmentsHernia repair and management