Water-soluble NHC Pd/Ni bimetallic nanoparticles for H/D exchange in aromatic amino-acids
Oscar Suárez-Riaño, Gabriel Mencia, Simon Tricard, Jérôme Esvan, Pier‐Francesco Fazzini, Bruno Chaudret, Edwin A. Baquero
Abstract
Labelling of amino-acids is important for the production of deuterated proteins. However, aromatic amino-acid reduction is a common undesired process with noble-metal nanocatalysts. In this work, we describe a new NHC-stabilized water-soluble Pd/Ni system able to perform H/D exchange reactions in an enantiospecific fashion without reducing the aromatic ring of phenylalanine and tyrosine thanks to a synergetic Pd-Ni effect.
Topics & Concepts
Aromatic amino acidsBimetallic stripChemistryNanomaterial-based catalystAmino acidPhenylalanineRing (chemistry)TyrosineCombinatorial chemistryCatalysisOrganic chemistryBiochemistryChemical Reactions and IsotopesAmmonia Synthesis and Nitrogen ReductionAsymmetric Hydrogenation and Catalysis