Ferroptosis: friend or foe in cancer immunotherapy?
Robin Demuynck, Iuliia Efimova, Elena Catanzaro, Dmitri V. Krysko
Abstract
Ferroptosis has gained interest due to it immunogenicity and the higher sensitivity of cancer cells to it. However, it was recently shown that ferroptosis in tumor-associated neutrophils leads to immunosuppression and negatively impacts therapy. Here, we discuss the potential implications of the two sides (friend versus foe) of ferroptosis in cancer immunotherapy.
Topics & Concepts
ImmunogenicityImmunotherapyImmunosuppressionCancerCancer immunotherapyMedicineImmunologyCancer researchCancer therapyImmune systemInternal medicineFerroptosis and cancer prognosisImmune cells in cancerCancer Immunotherapy and Biomarkers