PPARγ activation by pioglitazone does not suppress cravings for alcohol, and is associated with a risk of myopathy in treatment seeking alcohol dependent patients: a randomized controlled proof of principle study
Melanie L. Schwandt, Nancy Diazgranados, John C. Umhau, Laura E. Kwako, David T. George, Markus Heilig
Topics & Concepts
PioglitazoneCravingPlaceboProinflammatory cytokineContext (archaeology)MedicineAlcohol dependenceInternal medicinePeroxisome proliferator-activated receptorAlcoholPharmacologyEndocrinologyPsychologyAddictionReceptorPsychiatryChemistryDiabetes mellitusInflammationType 2 diabetesPathologyBiochemistryBiologyPaleontologyAlternative medicineNeurotransmitter Receptor Influence on BehaviorAlcohol Consumption and Health EffectsPeroxisome Proliferator-Activated Receptors