Insulin Resistance and Diabetes Mellitus in Alzheimer’s Disease
Jesús Burillo, Patricia Marqués, Beatriz Jiménez, Carlos González-Blanco, Manuel Benito, Carlos Guillén
Abstract
Type 2 diabetes mellitus is a progressive disease that is characterized by the appearance of insulin resistance. The term insulin resistance is very wide and could affect different proteins involved in insulin signaling, as well as other mechanisms. In this review, we have analyzed the main molecular mechanisms that could be involved in the connection between type 2 diabetes and neurodegeneration, in general, and more specifically with the appearance of Alzheimer's disease. We have studied, in more detail, the different processes involved, such as inflammation, endoplasmic reticulum stress, autophagy, and mitochondrial dysfunction.
Topics & Concepts
Insulin resistanceNeurodegenerationType 2 Diabetes MellitusDiabetes mellitusAutophagyDiseaseEndoplasmic reticulumMedicineInsulinInflammationInsulin receptorType 2 diabetesBioinformaticsEndocrinologyNeuroscienceInternal medicineBiologyCell biologyApoptosisGeneticsEndoplasmic Reticulum Stress and DiseasePancreatic function and diabetesAutophagy in Disease and Therapy