SPC25 overexpression promotes tumor proliferation and is prognostic of poor survival in hepatocellular carcinoma
Baozhu Zhang, Qing Zhou, Qiankun Xie, Xiaohui Lin, Wenqiang Miao, Zhaoguang Wei, Tingting Zheng, Zuoliang Pang, Haosheng Liu, Xi Chen
Abstract
BACKGROUND: The nuclear division cycle 80 (NDC80) complex assures proper chromosome segregation during the cell cycle progression. SPC25 is a crucial component of NDC80, and its role in hepatocellular carcinoma (HCC) has been explored recently. This study characterized the differential expression of SPC25 in HCC patients of different races and HBV infection status. METHODS: functional assays were conducted to explore the role of SPC25 in HCC. Bioinformatics methods were applied to investigate the regulatory mechanisms of SPC25. FINDINGS: by accelerating the cell cycle. We identified transcription factors, miRNAs, and immune cells that may interact with SPC25. INTERPRETATION: The findings suggest that increased expression of SPC25 is associated with poor prognosis of HCC and enhances the proliferative capacity of HCC cells. SPC25 could serve as a valuable prognostic marker and a novel treatment target for HCC.