Immune signatures underlying post-acute COVID-19 lung sequelae
In Su Cheon, Chaofan Li, Young Min Son, N. Goplen, Yue Wu, Tiffany J. Cassmann, Zheng Wang, Xiaoqin Wei, Jinyi Tang, Yichen Li, H. Marlow, Steven G. Hughes, L. Hammel, Tom Cox, Emma N. Goddery, Katayoun Ayasoufi, Daniela Weiskopf, Jim Boonyaratanakornkit, Haidong Dong, Hu Li, Rana Chakraborty, Aaron J. Johnson, Eric S. Edell, Justin J. Taylor, Mark H. Kaplan, Alessandro Sette, Brian J. Bartholmai, Ryan Kern, Robert Vassallo, Jie Sun
Abstract
T cells contributing to persistent tissue conditions after COVID-19. Our results have revealed pathophysiological and immune traits that may support the development of lung sequelae after SARS-CoV-2 pneumonia in older individuals, with implications for the treatment of chronic COVID-19 symptoms.
Topics & Concepts
Immune systemLungCoronavirus disease 2019 (COVID-19)Respiratory systemImmunologyCD8Lung infectionMedicineSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)2019-20 coronavirus outbreakBiologyVirologyPathologyInternal medicineDiseaseInfectious disease (medical specialty)OutbreakLong-Term Effects of COVID-19COVID-19 and Mental HealthInflammasome and immune disorders