Surfactant-driven modifications in protein structure
Sugam Kumar, Debasish Saha, Debes Ray, Vinod K. Aswal
Abstract
While the mechanisms of such refolding are still being explored, a general consensus suggests preferential binding of ionic surfactants with nonionic surfactants to form mixed micelles, rather than protein-surfactant complexes. It has also been demonstrated that the interaction of proteins with surfactants can be effectively utilized to guide the heat-induced gelation of proteins. This review article will summarize the fundamentals and recent updates on (i) protein interaction with surfactants; (ii) the phenomenon of protein unfolding and refolding, and (iii) the utilization of protein-surfactant interactions to direct heat-induced protein gelation.
Topics & Concepts
Pulmonary surfactantChemistryChemical engineeringBiophysicsNanotechnologyChemical physicsMaterials scienceBiochemistryBiologyEngineeringProtein purification and stabilityProtein Interaction Studies and Fluorescence AnalysisProtein Structure and Dynamics