Manganese oxide nanomaterials boost cancer immunotherapy
Binbin Ding, Jun Yue, Pan Zheng, Ping’an Ma, Jun Lin
Abstract
-sensitized photodynamic therapy (PDT), programmed cell death ligand-1 (PD-L1) expression downregulation, reprogramming tumor-associated macrophages (TAMs), and restraining tumor angiogenesis and lactic acid exhaustion), inducing immunogenic cell death (ICD), photothermal therapy (PTT) induction, activating the stimulator of interferon gene (STING) pathway and immunoadjuvants for nanovaccines. We hope that this review will provide holistic understanding about MONs and their application in cancer immunotherapy, and thus pave the way to the translation from bench to bedside in the future.
Topics & Concepts
Manganese oxideNanomaterialsImmunotherapyCancerCancer immunotherapyManganeseTumor microenvironmentCancer researchMaterials scienceNanotechnologyMedicineTumor cellsMetallurgyInternal medicineNanoplatforms for cancer theranosticsNanoparticle-Based Drug DeliveryAdvanced Nanomaterials in Catalysis