Photocatalytic difluoromethylarylation of unactivated alkenes <i>via</i> a (hetero)aryl neophyl-like radical migration
Ziran Lei, Siqi Wei, Liejin Zhou, Zuxiao Zhang, Simón E. López, William R. Dolbier
Abstract
Photoredox-catalyzed addition of the difluoromethylradical to unactivated alkenes has been found to trigger neophyl-like aryl and heteroaryl migrations which allowed the construction of a diverse series of difluoromethyl ketones. The reaction featured mild reaction conditions and broad substrate scope.
Topics & Concepts
ChemistryPhotocatalysisArylPhotochemistryAryl radicalCombinatorial chemistryOrganic chemistryCatalysisAlkylFluorine in Organic ChemistryRadical Photochemical ReactionsSulfur-Based Synthesis Techniques