<i>In Vitro</i> Activity of the Novel Tetracyclines, Tigecycline, Eravacycline, and Omadacycline, Against <i>Moraxella catarrhalis</i>
Xiang Sun, Bo Zhang, Guangjian Xu, Junwen Chen, Yongpeng Shang, Zhiwei Lin, Zhijian Yu, Jinxin Zheng, Bing Bai
Abstract
BACKGROUND: to tigecycline, eravacycline, and omadacycline and its resistance mechanisms against these tetracyclines. METHODS: pressure. The tet genes and mutations in the 16S rRNA was detected by PCR and sequencing. RESULTS: isolates increased 64-fold. Mutations in the 16S rRNA genes (C1036T and/or G460A) were observed in omadacycline-induced resistant isolates, and increased RR (the genes encoding 16SrRNA (four copies, RR1-RR4) copy number of 16S rRNA genes with mutations was associated with increased resistance to omadacycline. CONCLUSIONS: .
Topics & Concepts
TigecyclineBroth microdilutionMicrobiologyMoraxella catarrhalisMinimum inhibitory concentration16S ribosomal RNAChemistryBiologyAntimicrobialAntibioticsBacteriaStreptococcus pneumoniaeGeneticsAntibiotic Resistance in BacteriaAntibiotics Pharmacokinetics and EfficacyPharmaceutical and Antibiotic Environmental Impacts