Elevating sestrin2 attenuates endoplasmic reticulum stress and improves functional recovery through autophagy activation after spinal cord injury
Yao Li, Jing Zhang, Kailiang Zhou, Ling Xie, Guangheng Xiang, Mingqiao Fang, Wen Han, Xiangyang Wang, Jian Xiao
Topics & Concepts
AutophagyUnfolded protein responseEndoplasmic reticulumCell biologyProteostasisDownregulation and upregulationEndoplasmic-reticulum-associated protein degradationAMPKProgrammed cell deathIntegrated stress responseFlux (metallurgy)PI3K/AKT/mTOR pathwayTunicamycinGene knockdownChemistryBiologySignal transductionBiochemistryApoptosisPhosphorylationGeneProtein kinase ATranslation (biology)Messenger RNAOrganic chemistryAutophagy in Disease and TherapySpinal Cord Injury ResearchToxoplasma gondii Research Studies