The sparing effect of FLASH-RT on synaptic plasticity is maintained in mice with standard fractionation
Charles L. Limoli, Enikö A. Kramár, Aymeric Almeida, Benoît Petit, Veljko Grilj, Janet E. Baulch, Paola Ballesteros‐Zebadúa, Billy W. Loo, Marcelo A. Wood, Marie‐Catherine Vozenin
Abstract
Long-term potentiation (LTP) was used to gauge the impact of conventional and FLASH dose rates on synaptic transmission. Data collected from the hippocampus and medial prefrontal cortex confirmed significant inhibition of LTP after 10 fractions of 3 Gy (30 Gy total) conventional radiotherapy. Remarkably, 10x3Gy FLASH radiotherapy and unirradiated controls were identical and exhibited normal LTP.
Topics & Concepts
Long-term potentiationHippocampusSynaptic plasticityFlash (photography)NeuroscienceNeurotransmissionPrefrontal cortexChemistryBiologyMedicineInternal medicinePhysicsOpticsReceptorCognitionGlioma Diagnosis and TreatmentBrain Metastases and TreatmentAdvanced Memory and Neural Computing