Potassium Channel-Associated Bioelectricity of the Dermomyotome Determines Fin Patterning in Zebrafish
Martin R. Silic, Qiuyu Wu, Brian H Kim, Greg Golling, Kenny H. Chen, Renata Freitas, Alexander A. Chubykin, Suresh K. Mittal, Guangjun Zhang
Abstract
We found that all induce the long-finned phenotype, indicating that this function is conserved among potassium channel genes. Taken together, our results suggest that dermomyotome bioelectricity is a new fin-patterning mechanism, and we propose a two-stage bioelectricity model for zebrafish fin patterning. This ion channel-regulated bioelectric developmental patterning mechanism may provide with us new insight into vertebrate morphological evolution and human congenital malformations.
Topics & Concepts
ZebrafishBiologyPotassium channelFinPotassiumGeneticsCell biologyGeneBiophysicsChemistryMaterials scienceOrganic chemistryComposite materialIon channel regulation and functionPlanarian Biology and ElectrostimulationHearing, Cochlea, Tinnitus, Genetics